1/11/2024 0 Comments Blueprint cdk2![]() ![]() Blueprint Medicines is headquartered in Cambridge, Massachusetts, the US.įor a complete picture of BLU-222’s drug-specific PTSR and LoA scores, buy the report here. Cyclin E1 and E2 are core cell cycle regulators, that when bound activate CDK2 (cyclin-dependent kinase 2), driving G1/S progression of the cell cycle. The company utilizes its discover which combines bioinformatics and drug design capabilities to develop its medicines. Knutsford, UK, supported by Blueprint Medicines Corporation, Cambridge, MA. Blueprint Medicines is advancing pralsetinib inhibitor against RET (Ret Proto-Oncogene) modified medullary thyroid carcinoma and other solid tumors and avapritinib to treat advanced systemic mastocytosis. Preclinically, BLU-222 has shown potent CDK2 inhibition and antitumor. The company product pipeline includes AYVAKIT (avapritinib) medicine to treat gastrointestinal stromal tumor (GIST) and GAVRETO (pralsetinib) against non-small cell lung cancer in adults, BLU-263 targeting indolent systemic mastocytosis. Transformative science, targeted medicines. It acts by targeting cyclin dependent kinase 2 (CDK2).īlueprint Medicines, formerly Hoyle Pharmaceuticals, is precision therapy company that inventing medicines for people with cancer and blood disorders. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.īLU-222 is under development for the treatment of multiple CCNE driven cancers such as ovarian, ER positive HER2 negative breast, gastric cancer, prostate cancer and endometrial cancer. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. CAMBRIDGE, Mass. Abstract 2306: BLU-222, an investigational, potent, and selective CDK2 inhibitor, demonstrated robust antitumor activity in CCNE1 -amplified ovarian cancer. ![]()
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